Table 1 List of molecular targeted antineoplastic drugs with pediatric indications.

From: Gap between pediatric and adult approvals of molecular targeted drugs

ATC

Active ingredient

Pediatric indication

U.S

E.U

JP

L01XC02

Rituximab

N

N

Y

L01XC05

Gemtuzumab ozogamicin

Y

N

N

L01XC11

Ipilimumab

Y

Y

N

L01XC12

Brentuximab vedotin

N

N

Y

L01XC16

Dinutuximab

Y

Y

NA

L01XC17

Nivolumab

Y

N

N

L01XC18

Pembrolizumab

Y

N

N

L01XC19

Blinatumomab

Y

Y

Y

L01XC31

Avelumab

Y

N

N

L01XE01

Imatinib mesylate

Y

Y

N

L01XE06

Dasatinib

Y

Y

N

L01XE08

Nilotinib hydrochloride hydrate

Y

Y

Y

L01XE10

Everolimus

Y

Y

Y

L01XE12

Vandetanib

N

Y

N

L01XE53

Larotrectinib sulfate

Y

Y

NA

L01XE56

Entrectinib

Y

NA

Y

L01XX14

Tretinoin

Y

NA

Y

L01XX27

Arsenic trioxide

Y

N

Y

L01XX67

Tagraxofusp

Y

NA

NA

  1. ATC The anatomical therapeutic chemical codes; U.S. United States; E.U. European Union; JP Japan; Y Yes; N No; NA Not approved for either adults or children (as of February 2020).