Table 1 Baseline characteristics of the study population, before and after IPTW.
Before IPTW | After IPTW | |||||
|---|---|---|---|---|---|---|
Dronedarone (n = 3119) | Sotalol (n = 1575) | ASD | Dronedarone (N = 3123) | Sotalol (N = 1571) | ASD | |
Age, years | 63.2 ± 11.9 | 60.7 ± 12.9 | 0.20 | 62.7 ± 11.9 | 61.9 ± 12.9 | 0.04 |
Median (IQR) | 63 (55–72) | 62 (53–70) | 63 (55–71) | 63 (54–71) | ||
< 65 | 53.8 | 58.1 | 54.9 | 54.1 | ||
65–74 | 27.7 | 28.9 | 28.4 | 29.2 | ||
≥ 75 | 18.5 | 13.0 | 16.7 | 16.7 | ||
Men | 65.3 | 66.0 | − 0.01 | 65.6 | 65.5 | 0.00 |
CHA2DS2-VASc score | 2.72 ± 1.66 | 2.50 ± 1.62 | 0.13 | 2.66 ± 1.66 | 2.70 ± 1.67 | 0.02 |
Median (IQR) | 3 (1–4) | 2 (1–4) | 2 (1–4) | 2 (1–4) | ||
Charlson Comorbidity Index | 1.32 ± 1.49 | 1.21 ± 1.43 | 0.08 | 1.29 ± 1.47 | 1.32 ± 1.51 | 0.01 |
Median (IQR) | 1 (0–2) | 1 (0–2) | 1 (0–2) | 1 (0–2) | ||
Number of baseline AADs | 0.68 ± 0.70 | 0.70 ± 0.73 | 0.02 | 0.69 ± 0.71 | 0.70 ± 0.70 | 0.01 |
Median (IQR) | 1 (0–1) | 1 (0–1) | 1 (0–1) | 1 (0–1) | ||
0 | 43.4 | 44.4 | 43.2 | 42.2 | ||
1 | 46.3 | 43.4 | 45.8 | 46.8 | ||
≥ 2 | 10.2 | 12.5 | 11.0 | 10.9 | ||
Baseline AADs | ||||||
Flecainide | 15.8 | 23.9 | 0.20 | 19.1 | 19.5 | 0.01 |
Propafenone | 17.6 | 16.3 | 0.03 | 17.1 | 17.0 | 0.00 |
Pilsicainide | 8.0 | 4.7 | 0.14 | 6.9 | 6.7 | 0.01 |
Amiodarone | 26.9 | 25.0 | 0.05 | 26.3 | 27.0 | 0.01 |
Concomitant medication | ||||||
ß-blocker | 50.1 | 49.2 | 0.02 | 50.2 | 51.2 | 0.02 |
CCBs | 29.2 | 33.3 | 0.09 | 30.6 | 31.1 | 0.01 |
Digoxin | 4.8 | 8.6 | 0.15 | 5.8 | 5.9 | 0.00 |
ACE inhibitors or ARB | 7.9 | 7.9 | 0.00 | 7.8 | 7.9 | 0.00 |
Statins | 53.2 | 44.6 | 0.17 | 50.4 | 50.6 | 0.00 |
Warfarin | 29.1 | 38.0 | 0.19 | 32.2 | 33.0 | 0.02 |
Factor Xa inhibitors | 13.4 | 10.7 | 0.08 | 12.5 | 12.5 | 0.00 |
Aspirin | 46.8 | 42.9 | 0.08 | 45.7 | 46.5 | 0.02 |
Hospital type | ||||||
Tertiary hospital | 58.0 | 76.1 | 0.39 | 64.2 | 64.1 | 0.00 |
General hospital | 37.6 | 21.1 | 0.37 | 31.9 | 32.0 | 0.00 |
Hospital or general practitioner | 4.3 | 3.1 | 0.07 | 3.9 | 3.9 | 0.00 |
Insurance type | ||||||
Health insurance | 96.4 | 96.2 | 0.01 | 96.4 | 96.4 | 0.00 |
Medical aid | 3.6 | 3.8 | 3.6 | 3.6 | ||
Index year | ||||||
2013 | 12.3 | 10.5 | 0.06 | 11.7 | 11.9 | 0.01 |
2014 | 27.5 | 27.2 | 0.01 | 27.3 | 27.0 | 0.01 |
2015 | 27.6 | 34.6 | 0.15 | 30.0 | 30.6 | 0.01 |
2016 | 32.6 | 27.6 | 0.11 | 30.9 | 30.5 | 0.01 |
