Table 1 Dissociation constants (Kd) of the interactions between different whirlin constructs and the PCDH15 and CDH23 C-terminal peptides.
Whirlin fragments | PCDH15-CD1 | PCDH15-CD2 | PCDH15-CD3 | CDH23 |
|---|---|---|---|---|
NTR-PDZ1 + Hp1 | 8.8 ± 0.2 μM | 8.5 ± 1 μM | 4.2 ± 0.1 μM | 11.3 ± 0.8 μM |
PDZ1 + Hp1 | 29 ± 3 μM | 33 ± 2 μM | 11 ± 1 μM | 64 ± 6 μM |
PDZ1 | 106 ± 25 μM | 147 ± 50 μM | 34 ± 3 μM | 141 ± 80 μM |
PDZ2 | > 1 mM | > 1 mM | 460 ± 50 μM | > 1 mM |
PDZ3 | > 1 mM | > 1 mM | 230 ± 30 μM | 4.3 ± 0.3 μM |
HHD1 | > 1 mM | > 1 mM | > 1 mM | > 1 mM |
NTR | > 1 mM | > 1 mM | > 1 mM | > 1 mM |
