Figure 7 | Scientific Reports

Figure 7

From: Engineering and characterization of a novel Self Assembling Protein for Toxoplasma peptide vaccine in HLA-A*11:01, HLA-A*02:01 and HLA-B*07:02 transgenic mice

Figure 7

TEM images. After 24 h co-culture of bone marrow- derived dendritic cells (BMDDCs) from HLA-A*02:01 transgenic mice incubated with (a) GLA-SE alone, (b) ToxAll alone or (c) ToxAll with GLA-SE. GLA-SE present in particles mostly close to cell membranes with a size of ~ 100 nm (blue arrows). When incubated with ToxAll alone, lysosome of BMDDCs didn’t show any processing at 24 h. ToxAll plus GLA-SE interacts with lysosomal enzymes and shows a remarkably homogeneous distribution of particles in the lysosome. The red arrows indicate clusters of gold-encapsulated SAPN.

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