Table 1 Composition and characterization of 5FU-SLN.

From: Application of smart solid lipid nanoparticles to enhance the efficacy of 5-fluorouracil in the treatment of colorectal cancer

Formulation

5-FU (%w/v)

Lipid composition

Lipid ratio (%w/v)

Surfactant composition

Surfactant ratio (%w/v)

Mean particle size (nm)

Mean zeta potential (mV)

Polydispersity index (P.I)

5FU-SLN1

0.15

GM

2

TWN 80

1.5

288 ± 5

0.1 ± 0.02

0.3

5FU-SLN2

0.15

Compritol

3

TWN 80

4

170 ± 3

0.2 ± 0.05

1.4

5FU-SLN3

0.15

Precirol

3

TWN 80

4

228 ± 6

0.6 ± 0.02

1.2

5FU-SLN4

0.15

Precirol

3

TWN80/Lecithin

4:2

263 ± 3

1.1 ± 0.02

0.9

5FU-SLN5

0.15

Precirol

3

Poly/Lecithin

4:2

130 ± 5

0.5 ± 0.03

0.7

5FU-SLN6

0.15

Compritol

3

Poly/Lecithin

4:2

77 ± 3

0.2 ± 0.05

2.8

  1. All the formulations were freshly prepared.
  2. TWN 80, Tween 80; GM, Glycerol monostearate; Poly, Poloxamer.
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