Table 2 Pharmacokinetic parameters of free 5-FU and 5FU-SLN4 upon IP injection in the mice.

From: Application of smart solid lipid nanoparticles to enhance the efficacy of 5-fluorouracil in the treatment of colorectal cancer

Parameter

Unit

One-compartment model

Significance level

p-value

5-FU

5FU-SLN4

ka

1/h

1.36 ± 0.02

1.91 ± 0.04

0.0001

K10

1/h

1.01 ± 0.03

0.32 ± 0.02

0.0001

t1/2

h

0.68 ± 0.02

2.13 ± 0.04

0.0001

Vd

mL

14.3 ± 2.8

12.6 ± 0.6

0.3619

CL

mL/h

12.5 ± 1.3

4.1 ± 0.8

0.0007

Cmax

µg/mL

6.7 ± 0.4

12.7 ± 0.9

0.0005

Tmax

h

0.84 ± 0.06

1.12 ± 0.04

0.0025

AUC(0 − t)

µg/mL * h

15.5 ± 1.9

54.7 ± 3.2

0.0001

MRT

h

1.7 ± 0.4

3.6 ± 0.8

0.02

  1. Cmax, peak plasma concentration; Tmax, peak time; AUC(0 − t), area under the plasma concentration–time curve; MRT, mean residence time; k10, elimination rate constant; Cl, clearance; Vd, volume of distribution; ka, absorption rate constant (Data analyzed using unpaired t-test, two-tailed).
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