Table 4 Comparisons* of the CNV means between homozygous (R337H+/R337H+) and heterozygous (Wt/R337H+) human fibroblasts.

From: Frequency of the TP53 R337H variant in sporadic breast cancer and its impact on genomic instability

CNV > 10 kb

CNV > 50 kb

CNV > 100 kb

Chr

G/L

Hetero

Homo

P value

Chr

G/L

Hetero

Homo

P value

Chr

G/L

Hetero

Homo

P value

All chromosomes

chr1

G + L

4.7

20.4

0.022

chr1

L

0.5

1.5

0.038

chr10

L

0

0.7

0.046

chr1

G

10.1

42.0

0.033

chr1

G + L

2.5

6.7

0.033

chr14

G + L

0.8

1.8

0.028

chr2

G

4.7

14.7

0.027

chr2

G + L

2.7

5.8

0.049

chr15

L

0

0.7

0.046

chr3

G

4.2

16.8

0.043

chr3

G

0.8

3.4

0.006

chr15

G + L

1.7

3.8

0.017

chr6

G

2.3

7.0

0.040

chr3

G + L

1.8

6.1

0.037

chr15

G

0.5

2.3

0.016

chr7

G

1.2

25.3

0.032

chr5

G

0.3

2.0

0.028

chr16

G + L

0.5

2.4

0.016

chr8

G

3.0

15.7

0.041

chr7

G

0.3

4.7

0.028

     

chr10

G

6.3

32.0

0.030

chr7

G + L

0.5

6.1

0.004

     

chr10

G + L

8.0

37.8

0.022

chr10

G + L

1.8

6.4

0.038

     

chr11

G

2.7

13.3

0.042

chr14

G + L

1.8

5.7

0.031

     

chr11

G + L

4.8

24.1

0.034

chr15

G

2.1

4.7

0.023

     

chr13

G

0

2.6

0.014

chr15

L

0.7

3.1

0.043

     

chr14

G

2.5

6.1

0.029

chr15

G + L

2.8

7.8

0.008

     

chr15

G

3.5

8.4

0.041

chr16

G

1.0

4.8

0.024

     

chr16

G

2.6

18.8

0.040

chr16

G + L

1.3

6.4

0.048

     

chr22

G + L

2.3

19.1

0.029

chr19

L

0

1.7

0.045

     
     

chr20

G + L

0.2

1.0

0.041

     

Specific targets (11 and 11p15)

chr11p

G

1.3

6.3

0.039

chr11p

G + L

0.3

2.4

0.048

chr11p

L

0

0.7

0.046

chr11p

L

0.06

4.7

0.032

chr11p15 G + L

0

1.3

0.048

     

chr11p

G + L

2.0

11.0

0.014

          

chr11p15 G

0.5

5.0

0.023

          
  1. Only statistically significant differences (p < 0.05) are shown.
  2. *The comparisons were performed between homozygous (n = 8, 4 treated and 4 untreated assays) and heterozygous (n = 8, 4 treated and 4 untreated assays). Chr, chromosomes; G, gain; L, loss.
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