Figure 6
Solid Ehrlich tumor development (A), tumor weight (B) and tumor histology (C–F) and quantification (F) in mice. Animals were treated with vehicle p.o (Panel C), fruti 3 mg kg−1, p.o. (Panel D), or methotrexate, MTX, 2.5 mg/kg, i.p. (Panel E) for 21 days. Results are expressed as mean ± S.E.M. (n = 6–9) and were analyzed by two-way ANOVA followed by Bonferroni post hoc test (A) or one-way ANOVA followed by Newman Keuls post-hoc test (B). *p < 0.05 when compared to vehicle group. Black Arrows and head arrows indicated Ehrlich viable cells and coagulative necrosis area, respectively. Brown arrow indicates apoptotic cells. Samples were observed in optical microscope at 20× (scale bar 20 µm).
