Table 1 Oxidative stress and inflammatory parameters in Ehrlich tumor tissue.

From: Fruticuline A, a chemically-defined diterpene, exerts antineoplastic effects in vitro and in vivo by multiple mechanisms

Parameters

Experimental groups

Veh

Fruti

GSH (µg g of tissue−1)

197.51 ± 14.44

239.01 ± 39.71

DCFH-DA fluorescence

84.06 ± 1.02

96.69 ± 3.19*

MPO (µmol min−1 g of tissue−1)

164.07 ± 15.88

145.05 ± 11.16

NAG (µmol min−1 g of tissue−1)

20.03 ± 1.30

25.89 ± 2.89*

NO (µmol g of tissue−1)

8.13 ± 1.18

6.50 ± 0.58

TNF-α (pg mL−1)

1525.00 ± 212.05

2735.00 ± 352.09*

IL-4 (pg mL−1)

458.07 ± 88.78

456.09 ± 109.01

IL-6 (pg mL−1)

65.55 ± 5.13

96.63 ± 23.16

IL-10 (pg ml−1)

3232.00 ± 521.00

1050.00 ± 255.05*

  1. Animals were treated with fruti (3 mg kg−1, p.o.) or vehicle (Veh, 0.1% tween 20 in distilled water, 10 mL kg−1, p.o.) for 21 days. Results are expressed as mean ± S.E.M. (n = 5–7) and were analyzed by Student t-test.
  2. * p < 0.05 when compared to vehicle group.
Back to article page