Table 1 Interactions between the ciproxifan antagonist/inverse agonist and the receptor for residence times greater than 70%.
H3R ANTA | ||
|---|---|---|
Residue | Residence time (%) | |
PHE192 | 45.54 | 100.00 |
CYS188 | 45.5 | 100.00 |
ALA190 | 45.52 | 100.00 |
LEU111 | 3.29 | 100.00 |
TYR189 | 45.51 | 99.00 |
TRP110 | 3.28 | 99.00 |
ASP114 | 3.32 | 99.00 |
CYS87 | 2.57 | 97.00 |
GLY186 | 45.48 | 96.00 |
GLU191 | 45.53 | 96.00 |
CYS107 | 3.25 | 93.00 |
VAL83 | 2.53 | 83.00 |
PHE280 | 7.39 | 77.00 |
