Figure 5
From: Noninvasive temporal detection of early retinal vascular changes during diabetes
Diabetes-mediated retinal vascular changes in TSP1−/− STZ mice. (A) A significant decrease in pericytes cell counts was determined in TSP1−/− STZ mice compared with non-diabetic control mice (WT: 37.43 ± 3.10, STZ: 33.25 ± 3.54 (P = 0.0312). (B) A significant increase in E/P ratio was observed in TSP1−/− diabetic mice compared with control mice (WT: 3.92 ± 0.179, STZ: 4.29 ± 0.286 (P = 0.0130). (C) TSP1−/− STZ mice had a significantly greater number of branches than the control mice (WT: 40.63 ± 7.59, STZ: 55.42 ± 8.19 (P = 0.0032). (D) The control mice had significantly greater total mesh area than STZ mice (WT: 6266 ± 961.6, STZ 5007 ± 768.1 (P = 0.0145).
