Figure 4

Receiver operating characteristics (ROC) analysis. ROC analysis was applied to positive vs. negative SARS-CoV-2 samples as identified by RT-PCR assay for (a) S1 IgG-ELISA, (b) S1 IgM-ELISA, (c) N IgG-ELISA and (d) N IgM ELISA. Serum samples from healthy controls (n = 125) or COVID-19 patients collected during the 1st week (n = 10), 2nd week (n = 23), 3rd week (n = 14), or 4th week (n = 5) of symptoms-onset as well as all COVID-19 samples (n = 52). Correlation of (e) S1 and N IgG antibodies and (f) S1 and N IgM antibodies.