Table 4 Molecular status of ocular melanomas.

From: Clinical features and survival outcomes of ocular melanoma in a multi-ethnic Asian cohort

Gene (cases tested)

Number of cases

Uveal (%)

Conjunctival (%)

BRAF mutation (19)

V600E

0 (0)

4 (57.1)

S607F†

1 (8.3)

0 (0)

Not detected

11 (91.7)

3 (42.9)

CKIT mutation‡ (13)

Exon 11

1 (10)

0 (0)

Not detected

9 (90)

3 (100)

  1. †Lies within protein kinase domain of the Braf protein but actual effect on protein function remains unknown36.
  2. ‡Two point mutations at codon 558 (AAG to AAT) and codon 559 (GTT to ATT). Exons 9 and 11 were exclusively tested in 4 cases, an extended panel of exons 9, 11, 13 and 17 was tested in 7 cases. 1 patient was tested via a targeted gene panel while another was unknown.
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