Figure 8 | Scientific Reports

Figure 8

From: The liposomal delivery of hydrophobic oxidovanadium complexes imparts highly effective cytotoxicity and differentiating capacity in neuroblastoma tumour cells

Figure 8

Enhancement of AKT phosphorylation by liposomal AL3. (A) SK-N-SH cells were treated with BMOV or AL3 in solution, empty liposomes, or batch-1 AL3 liposomes (both dialysed and dialysed) for 3 days. An example immunoblot is shown showing pAKT stimulation levels; this is quantified in (B) along with two further datasets (n = 3). ANOVA was performed with Dunnett post hoc using untreated (UT) as the control, *p < 0.05, ***p < 0.001. (C) SK-N-SH were treated in the same way using batch 2 and 3 of the AL3 liposomes and the immunoblotting is shown; this blot is quantified in (D). Original gels are shown in Supplementary Figs. S8 and S9).

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