Table 1 Comparison among three TB tests (mIGRA, TST, and TB culture) in 39 cynomolgus monkeys (A) Agreement between the mIGRA and the TST, (B) Agreement between TB culture and the mIGRA and between TB culture and the TST.

From: Detection of tuberculosis in cynomolgus macaques (Macaca fascicularis) using a supplementary Monkey Interferon Gamma Releasing Assay (mIGRA)

TST

mIGRA

   

Negative

Positive

Total

Negative

23

6

29

   

Positive

2

8

10

   

Total

25

14

39

   

Cohen’s kappa coefficient (κ) value

0.524

Moderate agreement

   

p-value

0.0003

   

95% Confidence interval (CI)

0.2434–0.8053

   

TB culture

mIGRA

TST

Negative

Positive

Total

Negative

Positive

Total

Negative

24

7

31

26

5

31

Positive

1

7

8

3

5

8

Total

25

14

39

29

10

39

Cohen's kappa coefficient (κ) value

0.508

Moderate agreement

0.424

Moderate agreement

p-value

0.0004

0.0120

95% Confidence interval (CI)

0.2290–0.7868

0.0932–0.7555

  1. Cohen's kappa coefficient (κ) values, p-values and 95% confidence intervals (CIs) were calculated by Rstudio Version 1.3.1073 at https://www.rstudio.com (vcd package). The κ-value in the range of 0.41–0.6 means moderate agreement26. The italics indicate a total number of monkey cases found positive or negative. Bold is used for topics only such as Kappa value, p-value and CIs.
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