Figure 3

R-(−)-apomorphine and raloxifene are p-tau aggregation inhibitors (PTAIs) that act independently of the redox state of p-tau. (a) and (b) P-tau aggregation inhibition dose response curves of R-(−)-apomorphine and raloxifene. Aggregation of 6 µM of p-tau was done in the presence of the indicated concentrations of either compound. (c) Both R-(−)-apomorphine and raloxifene act independently of the two cysteine residues of p-tau. P-tau aggregation reactions with the C291S C322S (C/S) mutant p-tau were done in the presence of the indicated amounts of either compound. Shown are net changes of ThS over 16 h. R-(−)-apomorphine repetitively shows negative ThS net change at high doses.