Figure 7

Enhanced cytotoxicity of p-tau by benzodiazepines with the PTAE activity. SH-SY5Y cells were treated with 0–0.6 µM of p-tau in conjunction with varying doses of nitrazepam, prazepam or devazepide. Devazepide consistently showed stronger exacerbation on p-tau cytotoxicity, hence lower concentrations were used here. The red dotted lines indicate 50% viability. Curve fitting was done with the dose–response fitting function of the software Origin (version 8, OriginLab Inc.). The number in parentheses represents the concentration (in µM) of the indicated compound.