Table 5 Subgroup analysis of clinical characteristics for the association of SNPs with GC risk.

From: SNP-SNP interactions of oncogenic long non-coding RNAs HOTAIR and HOTTIP on gastric cancer susceptibility

 

Gender

Tumor origin

Pathology

 

Male

Female

p-value

Cardia

Cardia/Non-cardia

Non-cardia

p-value

Intestinal-type GC

Diffuse-type GC

Others

p-value

rs17720428

0.19

   

0.58

   

0.69

TT

80 (78.4%)

22 (21.6%)

 

56 (33.3%)

3 (66.7%)

43 (42.2%)

 

48 (47.1%)

20 (19.6%)

34 (33.3%)

 

TG

109 (70.3%)

46 (29.7%)

 

78 (50.6%)

3 (1.9%)

73 (47.4%)

 

81 (52.3%)

32 (20.6%)

42 (27.1%)

 

GG

35 (81.4%)

8 (18.6%)

 

27 (62.8%)

1 (2.3%)

15 (39.9%)

 

20 (46.5%)

7 (16.3%)

16 (37.2%)

 

rs7958904

0.31

   

0.54

   

0.85

GG

62 (77.5%)

18 (22.5%)

 

45 (56.3%)

2 (2.5%)

33 (41.3%)

 

37 (46.2%)

16 (20%)

27 (33.8%)

 

GC

110 (71%)

45 (29%)

 

80 (51.9%)

2 (1.3%)

72 (46.8%)

 

80 (51.6%)

32 (20.7%)

43 (27.7%)

 

CC

51 (79.7%)

13 (20.3%)

 

35 (54.7%)

3 (4.7%)

26 (40.6%)

 

32 (50%)

11 (17.2%)

21 (32.8%)

 

rs1899663

0.18

   

0.63

   

0.64

GG

80 (78.4%)

22 (21.6%)

 

55 (53.9%)

3 (2.9%)

44 (43.1%)

 

48 (47.1%)

20 (19.6%)

34 (33.3%)

 

GT

108 (70.1%)

46 (29.9%)

 

78 (51%)

3 (2%)

72 (47.1%)

 

81 (52.6%)

32 (20.8%)

42 (26.6%)

 

TT

35 (81.4%)

8 (18.6%)

 

27 (62.8%)

1 (2.3%)

15 (34.9%)

 

20 (46.5%)

7 (16.3%)

16 (37.2%)

 

rs4759314

0. 33

   

0.049

   

0.82

AA

212 (74.1%)

74 (25.9%)

 

155 (54.4%)

5 (1.8%)

125 (43.9%)

 

141 (49.3%)

57 (19.9%)

88 (30.8%)

 

AG

12 (85.7%)

2 (14.3%)

 

6 (42.9%)

2 (14.3%)

6 (42.9%)

 

8 (57.1%)

2 (14.3%)

4 (28.6%)

 

rs3807598

0.049

   

0.29

   

0.2

CC

61 (67.8%)

29 (32.2%)

 

43 (48.3%)

2 (2.3%)

44 (49.4%)

 

50 (55.6%)

19 (21.1%)

21 (23.3%)

 

CG

110 (81.5%)

25 (18.5%)

 

82 (60.7%)

3 (22.3%)

50 (37%)

 

58 (43%)

27 (20%)

50 (37%)

 

GG

52 (70.3%)

22 (29.7%)

 

36 (48.6%)

2 (2.7%)

36 (48.6%)

 

40 (54.1%)

13 (17.6%)

21 (28.4%)

 

rs17501292

0.08

   

0.96

   

0.44

TT

158 (76%)

50 (24%)

 

110 (52.9%)

5 (2.4%)

99 (44.7%)

 

97 (46.6%)

44 (21.2%)

67 (32.2%)

 

TG

59 (77.6%)

17 (22.4%)

 

42 (56%)

2 (2.7%)

31 (41.3%)

 

43 (56.6%)

14 (18.4%)

19 (25%)

 

GG

7 (50%)

7 (50%)

 

7 (50%)

0 (0%)

7 (50%)

 

8 (57.1%)

1 (7.1%)

5 (35.7%)

 

rs1859168

0.28

   

0.74

   

0.63

CC

206 (76%)

65 (24%)

 

145 (53.7%)

6 (2.2%)

119 (44.1%)

 

134 (49.4%)

53 (19.6%)

84 (31%)

 

CA

17 (63%)

10 (37%)

 

14 (51.9%)

1 (3.7%)

12 (44.4%)

 

14 (51.9%)

6 (22.2%)

7 (25.9%)

 

AA

1 (100%)

0 (0%)

 

1 (100%)

0 (0%)

0 (0%)

 

0 (0%)

0 (0%)

1 (100%)

 
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