Figure 2
From: Hydrojet-based delivery of footprint-free iPSC-derived cardiomyocytes into porcine myocardium
Detection of microparticle distribution in the porcine hearts using magnetic resonance imaging (MRI). (A) Determination of detectable microparticle amount in porcine hearts using 45,000 or 85,000 microparticles. A single injection of particles was performed using the new hydrojet system with tissue penetration pressure of E80 and injection pressure of E10 (E80/E10). The microparticles in the heart are highlighted by a red encircled region. (B) MRI of microparticles after the application of 85,000 microparticles (two injections) using 27G needle or the hydrojet system with tissue penetration pressures of E80 or E60 and an injection pressure of E10 (E80/E10 or E60/E10). (C) 3D reconstruction of particle distribution in porcine hearts using 3D Slicer software. (D) Comparison of microparticle distribution volume in porcine hearts. Results are shown as mean ± SD (n = 3). Statistical differences were determined using one-way ANOVA followed by Bonferroni’s multiple comparison test (*p < 0.05; **p < 0.01).
