Table 1 Macular telangiectasia type 2 clinical features of spectral domain optical coherence tomography.

From: Optical coherence tomographic features of macular telangiectasia type 2: Korean Macular Telangiectasia Type 2 Study—Report No. 1

Variable

Presenta

Mean logMAR VA (SE)b

P value*

N

%

Present

Absent

SD-OCT (ungradable 0 eyes)

166

100

   

Heidelberg OCT

104

62.7

   

Topcon 3D OCT

44

26.5

   

Zeiss OCT

18

10.8

   

Normal

11

6.6

   

Asymmetryc (N = 19)

7

36.8

0.108 (0.029)

0.078 (0.023)

0.270

Increased IR reflectivityc (N = 19)

3

15.8

0.090 (0.032)

0.090 (0.022)

0.998

IR hyporeflective cavities

121

72.9

0.271 (0.024)

0.312 (0.050)

0.424

Centre involvedd

111

91.7

0.259 (0.025)

0.390 (0.067)

0.067

Flattening of foveal floore (N = 121)

31

25.6

0.265 (0.045)

0.271 (0.028)

0.899

Internal limiting membrane drape

81

48.8

0.313 (0.029)

0.250 (0.032)

0.087

OR hyporeflective cavities (above ELM)

56

33.7

0.368 (0.044)

0.240 (0.025)

0.010

Centre involved

40

71.4

0.400 (0.049)

0.320 (0.078)

0.352

OR hyporeflective cavities (below ELM)

52

31.3

0.385 (0.042)

0.236 (0.027)

0.002

Centre involved

50

96.2

0.392 (0.042)

0.111 (0.000)

< 0.001

Collapsing OR layers

45

27.1

0.473 (0.040)

0.207 (0.022)

< 0.001

Disorganization of IR layers

52

31.3

0.422 (0.045)

0.206 (0.023)

< 0.001

HF

96

57.8

0.335 (0.035)

0.210 (0.026)

0.003

Clustered HF at the foveola

23

13.9

0.131 (0.032)

0.307 (0.026)

0.173

Increased reflectivity of the ONL

88

53.0

0.328 (0.036)

0.228 (0.027)

0.022

Increased reflectivity of ELM

27

16.3

0.258 (0.046)

0.287 (0.028)

0.586

ELM disruption

67

40.4

0.426 (0.042)

0.185 (0.022)

< 0.001

Centre involved

58

86.6

0.457 (0.046)

0.224 (0.062)

0.002

EZ disruption

87

52.4

0.391 (0.035)

0.163 (0.024)

< 0.001

Centre involved

79

90.8

0.402 (0.037)

0.232 (0.070)

0.024

IDZ disruption

94

56.6

0.367 (0.033)

0.174 (0.026)

< 0.001

Centre involved

88

93.6

0.378 (0.035)

0.127 (0.036)

< 0.001

Lamellar macular hole

4

2.4

0.359 (0.191)

0.280 (0.024)

0.683

Full thickness macular hole

5

3.0

0.636 (0.147)

0.272 (0.024)

0.016

Subretinal NV or other evidence of NV

14

8.4

0.553 (0.086)

0.258 (0.023)

0.001

  1. ELM external limiting membrane, EZ ellipsoid zone, HF hyperreflective foci, IDZ interdigitation zone, IR inner retinal, NV neovascularisation, ONL outer nuclear layer, OR outer retinal, SD-OCT spectral domain-optical coherence tomography, SE standard error, VA visual acuity.
  2. *P values were by generalised linear models and the generalised estimation equation method comparing the presence and absence of each finding.
  3. aProportion of each finding was calculated among gradable eyes.
  4. bMean logMAR VA was estimated by generalised linear models and the generalised estimation equation method to account for correlation between eyes.
  5. cAsymmetry and increased inner retinal reflectivity are only evaluated at the very early stage (MacTel severity score 0–2).
  6. dCentre involvement was defined as the presence of cavities within the foveal floor without the inner retinal layers or less than about 300–600 μm from the foveolar centre.
  7. eFlattening of foveal floor was only evaluated in patients with inner retinal hyporeflective cavities. Clustered hyperreflective foci was analysed in patients with only inner retinal cavity and MacTel severity score 0–2.
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