Figure 1
From: The KDEL trafficking receptor exploits pH to tune the strength of an unusual short hydrogen bond
Structures of the KDEL receptor used in this study. (a,c) KDEL peptide bound (PDB: 6i6h) and (b,d) the Apo (PDB: 6i6b) state. The hydrogen bond between E127 and Y158 is slightly shorter when peptide is bound at 2.5 Å (c) compared to 2.8 Å in the apo form (d). Atom labels used within this study are also shown along with the position of H12, which has previously be shown to act as the pH sensor. The approximate location of the membrane is shown with solid gray lines.
