Figure 2
MicroRNA-34a targets the colorectal cancer pathway. Genes targeted by miRNA34a are colored in orange. In the CRC pathway (KEGG: hsa05210)18,19, miR-34a-5p significantly targets 30 genes (P = 0.0013); including B-Raf proto-oncogene, serine/threonine kinase (BRAF), Ras-Related C3 Botulinum Toxin Substrate 2 (RAC2), phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), RAF1, B-cell lymphoma-2 (BCL2), BCL2 associated agonist of cell death (BAD), Baculoviral IAP repeat containing 5 (BIRC5), transforming growth factor beta 1 (TGFB1), TGFB3, TGFB-receptor 2 (TGFBR2), TCF7L1 (Transcription Factor 7 Like 1), ARAF, Tumor Protein P53 (TP53), AKT serine/threonine kinase 2 (AKT2), Jun proto-oncogene, AP-1 transcription factor subunit (JUN), cyclin D1 (CCND1), mothers against DPP homolog 4 (SMAD4), catenin beta 1 (CTNNB1), MutS homolog 6 (MSH6), axis inhibition proteins 2 (AXIN2), MYC proto-oncogene, BHLH transcription factor (MYC), mitogen-activated protein kinase 1 (MAPK1), MAPK3, MAPK8, mitogen-activated protein kinase kinase 1 (MAP2K1), caspase-9 (CASP9), Ral guanine nucleotide dissociation stimulator (RALGDS), lymphoid enhancer binding factor 1 (LEF1), cytochrome C, somatic (CYCS).
