Table 1 Genetic association models for MIR34A variant and cancer risk.

From: Analysis of microRNA-34a expression profile and rs2666433 variant in colorectal cancer: a pilot study

Genetic model

Genotype

Control

Cancer

OR (95% CI)

P-value

Heterozygote comparison

GG

30 (51.7)

13 (22.4)

Reference

0.017

 

AG

20 (34.5)

25 (43.1)

2.88 (1.20–6.93)

 

Homozygote comparison

GG

30 (51.7)

13 (22.4)

Reference

0.001

 

AA

8 (13.8)

20 (34.45)

5.76 (2.02–16.43)

 

Dominant model

GG

50 (86.2)

38 (65.5)

Reference

0.001

 

AA + AG

28 (13.8)

45 (77.6)

3.71 (1.66–8.29)

 

Recessive model

GG + AG

30 (51.7)

13 (22.4)

Reference

0.008

 

AA

8 (13.8)

20 (34.45)

3.29 (1.31–8.27)

 

Over-dominant model

GG + AA

38 (65.5)

33 (56.9)

Reference

0.34

 

AG

20 (34.5)

25 (43.1)

1.44 (0.68–3.05)

 

Allelic model

G

80 (69.0)

51 (44.0)

Reference

 < 0.001

 

A

36 (31.0)

65 (56.0)

2.83 (1.65–4.84)

 
  1. Values are shown as numbers (%). A Chi-square test was used. OR (95% CI), odds ratio, and 95% confidence interval. Bold values indicate statistically significant at P < 0.05.
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