Figure 9 | Scientific Reports

Figure 9

From: Magnetic separation of peripheral nerve-resident cells underscores key molecular features of human Schwann cells and fibroblasts: an immunochemical and transcriptomics approach

Figure 9

Auto and heterotypic interactions between SCs and fibroblasts in nerve regeneration. The RNA-seq profiling unmasked key hypothetical connections among human SCs and fibroblasts operating via multiple signaling mechanisms. Paracrine signaling from SCs and fibroblasts targeting neurons and/or other cellular components within the nerves, such as the vasculature and immune cells (not shown), can also be anticipated based on RNAseq profiling. Examples of potential molecular players mediating autocrine (red arrows) and paracrine (blue and green arrows) interactions are described in Figs. 7 and 8, and the text.

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