Figure 3
The MF mice got TMJOA-like pathological changes and increased leptin expression compared to Control. (A) The histological morphology of the condylar cartilage of MF mice and Control (400 ×). (B) The cartilage thickness of different layers in MF mice and Control (T: total layer; F: fibrous layer; P: proliferative layer; H: hypertrophic layer). (C) The expression of inflammatory factor, IL-1β in the condylar cartilage of MF mice and Control. (D) Immunohistochemical scores of IL-1β after force applying for 7 days. (E) The expression of cartilage matrix degradation enzyme, MMP-3 in the condylar cartilage of MF mice and Control. (F) Immunohistochemical scores of MMP-3 after force applying for 7 days. (G) Leptin expression in the condylar cartilage of MF mice and Control. (H) Immunohistochemical scores of leptin after force applying for 7 days. *P < 0.05.
