Figure 1

Many TFs bind to tDNA regions. Distribution of TFs at chr17:81,000,000–8,150,000 (a) and chr15:4,517,500–45,225,000 (b) in K562 cells. The regions bound by individual TFs are indicated with a green bar. (c) Distance between each tDNA and each TF binding region in K562. Upstream positions are shown to the left of 0 bp, and downstream positions are shown to the right; 0 bp indicates that the TF was bound to the tDNA. The 75th, 50th and 25th percentile values of the number of TFs bound to each position are indicated by green, red and blue lines, respectively. (d) The number of TFs bound to each tDNA in K562 and HeLa-S3 cells. tDNAs to which many TFs were bound in K562 cells but not GM12878 cells are shown as red data points. (e) The cumulative number of TFs bound to tDNAs in each cell line.