Table 5 Multivariable logistic regression analyses of all opportunistic pathogens evaluated in this study on each type of vaginal microbiota.

From: Vaginal microbiota evaluation and prevalence of key pathogens in ecuadorian women: an epidemiologic analysis

Type of vaginal microbiota

Opportunistic pathogen

P-value

OR

95% CI

Adjusted P-value

Healthy microbiota

Atopobium vaginae

0.107

0.69

0.43–1.09)

0.161

Mobiluncus mulieris

0.008**

0.06

0.01–0.49

0.048*

Gardnerella spp.

0.023*

0.59

0.37–0.93

0.069

Escherichia coli

0.185

0.64

0.34–1.23

0.222

Enterococcus faecalis

0.698

0.73

0.14–3.68

0.698

Candida albicans

0.063

0.13

0.02–1.12

0.126

Intermediate microbiota

Atopobium vaginae

0.484

1.28

0.64–2.55

0.654

Mobiluncus mulieris

0.545

0.52

0.06–4.30

0.654

Gardnerella spp.

0.245

1.50

0.76–2.99

0.654

Escherichia coli

0.720

1.18

0.48–2.94

0.720

Enterococcus faecalis

0.362

2.28

0.39–13.37

0.654

Candida albicans

0.374

2.20

0.39–12.58

0.654

Bacterial vaginosis

Atopobium vaginae

0.657

1.24

0.48–3.25

0.709

Mobiluncus mulieris

0.020*

4.98

1.28–19.39

0.060

Gardnerella spp.

0.010**

4.16

1.40–12.35

0.060

Escherichia coli

0.490

0.63

0.17–2.37

0.709

Enterococcus faecalis

0.481

2.31

0.22–23.85

0.709

Candida albicans

0.709

1.54

0.16–15.03

0.709

Aerobic vaginitis

Atopobium vaginae

0.536

0.81

0.41–1.59

0.999

Mobiluncus mulieris

0.080

3.29

0.87–12.50

0.240

Gardnerella spp.

0.800

0.92

0.47–1.80

0.999

Escherichia coli

0.009**

2.81

1.29–6.12

0.054

Enterococcus faecalis

0.990

0.99

0.10–9.59

0.999

Candida albicans

0.999

0.00

0.00–N/d

0.999

Candidiasis

Atopobium vaginae

0.095

6.62

0.72–60.79

0.285

Mobiluncus mulieris

0.999

0.00

0.00–Nd

0.999

Gardnerella spp.

0.703

1.44

0.22–9.19

0.999

Escherichia coli

0.405

2.14

0.36–12.89

0.810

Enterococcus faecalis

0.999

0.00

0.00–N/d

0.999

Candida albicans

0.007**

17.94

2.22–145.11

0.042*

Coinfections

Atopobium vaginae

0.056

3.34

0.97–11.54

0.168

Mobiluncus mulieris

0.033*

5.48

1.15–26.18

0.168

Gardnerella spp.

0.359

1.76

0.52–5.94

0.431

Escherichia coli

0.229

0.27

0.03–2.26

0.431

Enterococcus faecalis

0.999

0.00

0.00–N/d

0.999

Candida albicans

0.296

3.50

0.33–36.64

0.431

  1. Legend: Multivariable logistic regression analyses were conducted to examine how different opportunistic pathogens (independent variables) were simultaneously associated with each type of vaginal microbiota diagnosis (dependent variables). Each type of vaginal infection (BV, VC, AV, and co-infection), healthy microbiota, and intermediate microbiota were considered categorical variables (dependent variables) for testing against different opportunistic pathogens (independent variables) detected in each type of vaginal microbiota. A value of P < 0.05 and 95% confidence intervals were considered significant for the test: *P ≤ 0.05; **P ≤ 0.01. N/d non-determined. All initial values of P < 0.05 obtained by multivariable logistic regression analyses were then evaluated through Benjamini–Hochberg (BH) adjustment to detect false discovery rate (FDR) for conducting multiple comparisons. These P-values evaluated by BH adjustment were illustrated in the table as adjusted P-values.
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