Figure 5

SDH immunostaining and PGC1-α expression levels in the gastrocnemius muscles. (A) Representative immunostaining of SDH. a, Sham mice; b, 5/6Nx mice; c, 5/6Nx mice treated with control-aptamer; d, 5/6Nx mice treated with AGE-aptamer. (B) Quantitative data of SDH immunostaining. n = 5–10 per each group. (C) Protein expression levels of PCG1-α. Upper panel shows representative bands of western blot analysis. Lower panel shows the quantitative data. n = 4–5 per each group. ‡ and ‡‡, p < 0.05 and p < 0.01 compared with 5/6Nx mice plus control-aptamer, respectively. Full-length blots are presented in Supplementary Figure S1.