Figure 1 | Scientific Reports

Figure 1

From: HLA-A alleles including HLA-A29 affect the composition of the gut microbiome: a potential clue to the pathogenesis of birdshot retinochoroidopathy

Figure 1

(A) sPLSDA and PERMANOVA analysis of bacterial species composition (beta diversity) of the Portland cohort. Controlling for covariates (gender, ethnicity, age and BMI) and accounting for repeated sampling, significant differentiation of the species composition according to HLA-A29 status was noted. (B) Bacterial species richness (alpha diversity) across six sampling sites in the Portland cohort. Consistent with results noted for HLA-B27 and HLA-DRB1, carriage of HLA-A29 is not associated with a difference in the number of detectable bacterial species. (C) Alpha and beta diversity (sPLSDA and PERMANOVA) analysis of bacterial species (a.k.a. taxonomic) composition of the HMP cohort. Controlling for covariates (smoking, age, BMI, gender and ethnicity) and accounting for repeated sampling, significant differentiation was noted. No difference in alpha diversity was noted. (D) Alpha and beta diversity (sPLSDA and PERMANOVA) analysis of the overall metabolic/functional composition of the microbiome for individuals in HMP cohort. No significant differences were noted, consistent with observations that the functional composition of the microbiome is relatively stable across individuals compared to the taxonomic/species composition. Plots were generated using the mixOmics26 and ggplot2 packages as part of R.

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