Figure 2 | Scientific Reports

Figure 2

From: Systemic and sustained thioredoxin analogue prevents acute kidney injury and its-associated distant organ damage in renal ischemia reperfusion injury mice

Figure 2

Protective effect of HSA-Trx against lung injury in renal IR-mice. (A) Representative micrographs of HE-stained lung tissues and (B) a semi-quantitative scoring analysis of alveolar cavity area, the number of alveoli, and alveolar wall thickness at 36 h after renal IR in sham mice and renal IR-mice treated with PBS, a mixture of HSA and Trx, or HSA-Trx alone. Lower panels of HE show an enlarged image of the upper panel. Original magnifications: × 200 (upper panels); × 400 (lower panels). Scale bars represent 100 μm. Four high-magnification (× 200) fields in a lung section were randomly selected for the semi-quantitative analysis of morphological changes. (C) Protein concentration in BALF, which is increased by pulmonary hyper-permeability, was determined at 36 h after renal IR. Data are expressed as the means ± SD (n = 5–6). *P < 0.05, **P < 0.01 compared with renal IR-mice administered with the 1:1 mixture of HSA plus Trx.

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