Figure 3

Mutational landscape of Lung Adenocarcinoma. (A) Diagram summarizing the sample inclusion criteria applied for the analysis of the LUAD TCGA dataset. Patients with both survival and tobacco consumption information, and including at least 50 SNV in their genome were analyzed (n = 418). Samples were used for tri- and tetra-nucleotide signature extraction. Pie charts summarize the distribution of smoking status and prognosis in the included patients. (B) Violin plot showing the distribution of total number of mutations detected in LUAD cancer genomes according to the patients’ smoking status. Blue dots indicate the median values; blue segments indicate the range spanning from the first to the third quartile. Groups were compared by t-test. (C) Plot comparing survival of LUAD cancer patients according to tumor stage (I to IV). Groups were compared by log-rank test. Three asterisks (***) indicate p-value less than 1e−4 for the labelled group compared to all others. Plots were generated using R software version 3.6.3 (R Core Team, 2020. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.R-project.org/).