Table 1 Hoy solubility parameters of enzalutamide and select cellulose-based polymers.

From: Amorphous solid dispersions of enzalutamide and novel polysaccharide derivatives: investigation of relationships between polymer structure and performance

Compound

Total solubility parameter (δt) (J1/2 cm−2/3)

Polar solubility parameter (δp) (J1/2 cm−2/3)

Hydrogen bonding solubility parameter (δh) (J1/2 cm−2/3)

Dispersive solubility parameter (δd) (J1/2 cm−2/3)

Aqueous solubility (mg/mL)

Enzalutamide

31.4

4.3

15.2

27.1

0.042a

HPMCAS-MF

25.8

16.0

14.6

14.1

23.4

CA Sub

21.0

12.1

8.2

15.1

3.0

CPHPC-106

23.4

14.4

11.4

14.4

43.5

  1. aAmorphous solubility.
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