Table 3 Name, abbreviation, and structure of polymers used in this study.

From: Amorphous solid dispersions of enzalutamide and novel polysaccharide derivatives: investigation of relationships between polymer structure and performance

Name

Abbreviation

Structure

Substituent/AHG

Hydroxypropyl methyl cellulose acetate succinate (MF grade)

HPMCAS

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Hydroxypropyl methyl cellulose (E3 grade)

HPMC

 

Poly(vinylpyrrolidone) vinyl acetate VA 64

PVPVA

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Poly(vinylpyrrolidone) K 29/32

PVP

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Cellulose acetate phthalate

CA Ph

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Hydroxypropyl cellulose

HPC

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5-Carboxypent-1-yl hydroxypropyl cellulose26

CPHPC-106

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DS(HP): 2.20

MS(HP): 4.40

DS(CP): 1.06

5-Carboxypent-1-yl hydroxypropyl cellulose26

CPHPC-282

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DS(HP): 2.20

MS(HP): 4.40

DS(CP): 2.82

5-Carboxyprop-1-yl hydroxypropyl cellulose26

CPHPC-069

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DS(HP): 2.2

MS(HP): 4.4

DS(CPr): 0.69

Cellulose backbone structure

 

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Cellulose propionate trioxodecanoate11

CPTod-202

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DS(Pr): 0.98

DS(TOD): 2.02

Cellulose acetate adipate poly(ethylene glycol) ester11

CAAd PEG

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DS(Ac): 1.82

DS(Ad): 0.56

Cellulose acetate adipate hydroxyethyl ester11

CAAd HOEt

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DS(Ac): 1.82

DS(Ad): 0.56

Cellulose acetate adipate propionate37

CAAdP 0.85

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DS(Ac): 0.04

DS(Pr): 2.09

DS(Ad): 0.85

Cellulose acetate adipate37

CAAd 0.67

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DS(Ac): 1.82

DS(Ad): 0.67

Cellulose acetate suberate37

CA Sub

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DS(Ac): 1.82

DS(Sub): 0.90

Cellulose acetate 3-(2-carboxyethylthio)-adipate, hydroxyethyl ester11

CAAd 3CES HE

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DS(Ac): 1.82

DS(Ad): 0.79

Cellulose acetate 9-(2-carboxyethylthio)-Undecanoate, 2-(trimethylammonio)-ethyl ester11

CAUn 3CES TAE

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DS(Ac): 1.82

DS(Un): 0.67

Methyl cellulose adipate25

MCAd

DS(Me): 1.62

DS(Ad):1.1

Methyl 5-carboxypentyl cellulose25a

MCCP-A

DS(Me): 1.62

DS(CP): 1.37

Methyl 5-carboxypentyl cellulose25a

MCCP-B

DS(Me): 1.62

DS(CP): 1.37

Ethyl cellulose backbone

 

 

Ethyl 5-carboxypentyl cellulose25a

ECCP-A

Starting source commercial ethyl cellulose

DS(Et): 2.58

DS(CP): 0.38

Ethyl 5-carboxypentyl cellulose25a

ECCP-B

Starting source commercial ethyl cellulose

DS(Et): 2.58

DS(CP): 0.38

Ethyl 5-carboxypentyl cellulose25b

ECCP-C

Starting source wood pulp

DS(Et): 2.19

DS(CP): 0.36

Ethyl 5-carboxypentyl cellulose25b

ECCP-D

Starting source commercial methyl cellulose

DS(Et): 2.2

DS(CP): 0.56

  1. Note that all structures above are not meant to imply regioselective substitution; they are depicted this way only for clarity and simplicity.
  2. AHG anhydroglucose unit.
  3. aPolymers differ only in how they are hydrogenated in the final synthetic step.
  4. bPolymers differ in DS (degree of substitution, Et) of starting material and therefore product from those above.