Figure 10 | Scientific Reports

Figure 10

From: Transport of ultrasmall gold nanoparticles (2 nm) across the blood–brain barrier in a six-cell brain spheroid model

Figure 10

Effect of hypoxia on the uptake of Au-Click-FAM nanoparticles or FAM-alkyne after 30 min incubation after 24 h hypoxia. The nanoparticles entered the spheroid and were also found in the external pericyte/endothelial cell layer. The dissolved FAM-alkyne molecules also entered the spheroid to a considerable extent. This demonstrates the hypoxia-induced damage to the blood–brain barrier. Scale bars 200 µm.

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