Figure 4 | Scientific Reports

Figure 4

From: Transport of ultrasmall gold nanoparticles (2 nm) across the blood–brain barrier in a six-cell brain spheroid model

Figure 4

Uptake of ultrasmall FAM-labelled gold nanoparticles (Au-Click-FAM) and dissolved FAM-alkyne by brain spheroids after 30 min, 6 h, and 24 h. The nanoparticles and the dye showed a green fluorescence. The nanoparticles clearly entered the center of the spheroid whereas the dye FAM-alkyne was mostly rejected. Notably, the nanoparticles were mainly present in the center of the organoid and not in the outer pericyte/endothelial cell layer. Scale bars 200 µm.

Back to article page