Table 2 Summary of Receiver Operating Characteristic (ROC) analysis, favourable vs unfavourable outcome following TBI, of MMPs and brain injury biomarkers in CSF.

From: Dynamics of cerebrospinal fluid levels of matrix metalloproteinases in human traumatic brain injury

MMP

AUC

Cut off (pg/mL)

Sensitivity (%)

Specificity (%)

MMP-1

0.705

85.3

91.7

61.5

MMP-2

0.769*

2380

83.3

69.2

MMP-3

0.679

114

100

46.2

MMP-9

0.468

133

75.0

38.5

MMP-10

0.846*

166

83.3

76.9

MMP-12

0.635

9.75

66.7

69.2

Biomarker

AUC

Cut off (ng/mL)

Sensitivity (%)

Specificity (%)

NFL

0.969**

3480

100

87.5

S100B

0.766

22.8

100

50.0

NSE

0.672

43.0

100

50.0

  1. Statistical significance in the CSF analyte concentrations between favourable and unfavourable outcomes in TBI: *p ≤ 0.05. Receiver Operating Characteristic analysis was performed to predict the unfavourable outcome following TBI.
  2. AUC area under the curve, MMP matrix metalloproteinase, NFL neurofilament light, NSE neuron-specific enolase, S100B S100 calcium-binding protein B.
Back to article page