Figure 1 | Scientific Reports

Figure 1

From: Dipeptidyl peptidase-4 inhibitor protects against non-alcoholic steatohepatitis in mice by targeting TRAIL receptor-mediated lipoapoptosis via modulating hepatic dipeptidyl peptidase-4 expression

Figure 1

DPP4i ameliorates histopathological phenotype of NASH and reduces fibrotic and pro-inflammatory markers in the AMLN diet-induced NASH mouse model. Representative histopathological images of H&E staining (a) and MT staining (b) in vehicle-treated chow-fed mice, vehicle-treated AMLN-fed mice, and DPP4i-treated AMLN-fed mice (200 × magnification, scale bar: 200 μm). Graphs showing liver to body weight ratio (c), hepatic triglycerides level (d), and relative mRNA expression levels of collagen1α1 (e), αSMA (f), TGF-β1 (g), and MCP-1 (h) by qPCR according to the diet type and DPP4i administration at 20th week. Data in all graphs are presented as mean ± SEM. *p < 0.05; **p < 0.01; NS, not statistically significant. Chow, vehicle-treated chow-fed mice; AMLN, vehicle-treated AMLN-fed mice; AMLN + DPP4i, DPP4i-treated (teneligliptin 20 mg/kg of body weight/day by oral gavage for 10 weeks) AMLN-fed mice.

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