Table 3 Correlation between the relative DPP4 mRNA expression levels, biochemical indices, and the NAFLD activity score.

From: Dipeptidyl peptidase-4 inhibitor protects against non-alcoholic steatohepatitis in mice by targeting TRAIL receptor-mediated lipoapoptosis via modulating hepatic dipeptidyl peptidase-4 expression

N = 29

Liver DPP4 mRNA

r

p-value

Body weight (g)

0.51

< 0.01

Liver weight (g)

0.57

< 0.01

Liver to body weight (%)

0.57

< 0.01

NAFLD activity score

0.55

< 0.01

Hepatic triglyceride (mg/g)

0.64

< 0.01

Fasting serum glucose (mg/dL)

0.16

0.42

Fasting serum insulin (ng/dL)

0.08

0.67

Serum total cholesterol (mg/dL)

0.56

< 0.01

Serum free fatty acids (mM)

0.40

0.05

Serum AST (IU/L)

0.70

< 0.01

Serum ALT (IU/L)

0.63

< 0.01

TRAIL-R2 mRNA

0.63

< 0.01

  1. Data are presented as Spearman’s rank correlation coefficient (r). p < 0.05 was regarded as statistically significant.
  2. ALT, alanine aminotransferase; AST, aspartate aminotransferase; DPP4, dipeptidyl peptidase-4; NAFLD, non-alcoholic fatty liver disease; TRAIL-R2, TNF-related apoptosis-inducing ligand receptor 2.
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