Table 5 Characteristics and SPM and eicosanoid levels in morbidly obese nondiabetic subjects compared to diabetic subjects before and after bariatric surgery.

From: The relationship between specialized pro-resolving lipid mediators, morbid obesity and weight loss after bariatric surgery

	Nondiabetic subjects (n = 16)			Diabetic subjects (n = 13)
	Pre-surgery	Post-surgery	p^a	Pre-surgery	Post-surgery	p^b	p^c	p^d
Wt (lb)	314.5 ± 46.0	178.0 ± 27.3	< 0.001	295.7 ± 43.3	170.6 ± 26.2	< 0.001	0.97	0.76
BMI^e	53.3 ± 7.6	28.8 ± 4.6	< 0.001	52.7 ± 7.2	28.9 ± 4.3	< 0.001	0.77	0.58
WBC^f	8.41 ± 2.29	5.74 ± 2.08	< 0.001	8.64 ± 3.54	6.39 ± 1.75	0.007	0.46	0.58
Platelets^g	252.1 ± 81.2	195.1 ± 75.0	< 0.001	254.5 ± 96.3	232.2 ± 125.9	0.10	0.82	0.49
Docosahexaenoic acid metabolome (ρg/ml)
RvD1	4.8 [3.9, 8.5]	4.3 [3.4, 5.7]	0.33	5.4 [3.1, 8.9]	6.1 [5, 2, 12.3]	0.22	0.78	0.045
RvD3	2.5 [1.8, 3.2]	1.5 [1.3, 2.3]	0.026	2.1 [1.6, 2.7]	1.6 [1.5, 2.4]	0.60	0.42	0.45
RvD4	245.7 [145.5, 432.8]	179.9 [123.6, 426.1]	0.38	228.0 [141.1, 366.7]	188.8 [125.2, 370.8]	0.55	0.62	0.98
17 HDHA	99.9 [77.9, 153.5]	69.1 [39.5, 133.8]	0.026	88.1 [57.8, 124.0]	56.2 [42.6, 116.7]	0.60	0.37	0.95
PD1	68.9 [58.0, 83.9]	43.2 [39.6, 70.3]	0.002	64.2 [47.9, 83.7]	59.1 [39.9, 75.9]	0.65	0.56	0.50
14-HDHA	558.7 [213.5, 806.2]	345.7 [203.4, 845.2]	0.50	254.0 [56.2, 708.1]	401.1 [126.3, 942.9]	0.65	0.22	0.85
Mar1	9.5 [0, 34.2]	30.0 [1.3, 47.7]	0.43	8.8 [0, 21.2]	0 [0, 6.2]	0.21	0.81	0.012
Eicosapentaenoic acid metabolomes (ρg/ml)
RvE1	0 [0, 0]	0 [0, 0]	0.32	0 [0, 0]	0 [0, 0]	1.00	0.78	1.00
18-HEPE	44.0 [26.6, 67.9]	31.2 [20.9, 53.4]	0.070	36.2 [24.4, 61.2]	34.6 [20.0, 61.2]	0.38	0.56	0.98
Arachidonic acid metabolomes (ρg/ml)
LTB₄	29.0 [0, 109.5]	22.4 [2.0, 57.2]	0.18	15.2 [0, 38.8]	0 [0, 43.0]	1.00	0.48	0.25
PGD₂	6.3 [3.1, 8.2]	6.0 [3.2, 8.8]	0.20	4.1 [2.5, 9.6]	4.6 [2.7, 8.2]	0.70	0.62	0.56
PGE₂	19.0 [5.1, 70.9]	37.0 [14.0, 84.0]	0.72	13.8 [0, 39.5]	16.9 [9.4, 29.6]	0.81	0.29	0.11

BMI Body mass index, LTB₄ leukotriene B₄, MaR1 maresin 1, PD1 protectin D1, ρg picogram, PGD₂ prostaglandin D₂, PGE₂ prostaglandin E₂, RvD1 resolvin D1, RvD3 resolvin D3, RvD4 resolvin D4, RvE1 resolvin E1, Wt weight, 14-HDHA 14-hydroxy-docosahexaenoic acid, 17-HDHA 17-hydroxy-docosahexaenoic acid, 18-HEPE 18-hydroxy-eicosapentaenoic acid.
Continuous variables are presented as mean ± SD or median [interquartile range].
A 2-sided p value ≤ 0.05 was considered statistically significant.
^ap value comparing nondiabetic subjects pre-surgery to post-surgery.
^bp value comparing diabetic subjects pre-surgery to post-surgery.
^cp value comparing nondiabetic subjects to diabetic subjects pre-surgery.
^dp value comparing nondiabetic subjects to diabetic subjects post-surgery.
^eBMI expressed as kg/m².
^fWBC expressed as 10⁹ cells/l.
^gPlatelets expressed as cells/µl.

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Table 5 Characteristics and SPM and eicosanoid levels in morbidly obese nondiabetic subjects compared to diabetic subjects before and after bariatric surgery.

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