Figure 5

Summary of the expression levels of TCF4 alternative 5′ and internal exons in FECD. Schematic depiction of the human TCF4 gene structure and transcripts which displayed high expression levels in RNA-seq data analysis (see Figs. 4, 5). Internal exons are depicted as boxes (3–21) and 5′ exons are shown as columns on top or under the internal exons. Name of the respective TCF4 exon is shown inside the box. Splicing of 5′ exons is shown by black lines which lead to the respective internal exon. Isoform encoded by the transcript is indicated as a single character (A, B, C, D, E, H or I) marked bold on the line next to the 5′ exon. 5′ exons marked green or red display significantly increased or decreased expression, respectively, in FECD, when spliced to the respective internal exon. Internal exons are connected by green, blue or red lines. A green or a red line between internal exons indicates a significant increase or decrease, respectively, in the expression level of transcripts containing splicing between these exons in FECD. A blue line or box indicates no change in the levels of transcripts containing splicing between these exons. The CTG TNR is marked between internal exons 3 and 4 as a grey box (CTG).