Figure 3
Molecular degree of perturbation among children with tuberculosis during treatment and uninfected controls, by participant age and sex. (A) Histograms show the single sample molecular degree of perturbation (MDP) score values for controls at baseline (blue), cases before treatment (green), cases after 1 month of treatment (orange), and TB cases after 6 months of treatment (dark yellow). (B) Out of these groups, MDP was significantly higher among cases before treatment (green) and cases after 1 month of treatment (orange) than among controls. MDP was not significantly different between cases after treatment (yellow) and controls (blue). (C) MDP was not significantly different by sex in any study group. (D) MDP was positively correlated with increasing age of participant among cases before treatment, but not among other study groups.
