Figure 4

Comparison of ganglion cell-inner plexiform layer (GCIPL) thickness measurements as extracted using the Goldmann III visual field-based (VF-based) paradigm and 8 × 8 grid, with a participant’s GCIPL thickness map underneath. In the top panel, as per Fig. 3 (middle row, right column), the foveal measurements are depicted in dark blue, locations where median differences compared with instrument review software-derived 8 × 8 grid measurements were greater than + 3.9 μm and less than − 3.9 μm are coloured pale blue and pale red respectively, and all other locations are depicted in white. Within the grid squares highlighted in green (A–C), GCIPL thickness profiles along chosen locations (black arrows) were extracted from the instrument review software (bottom panels (A–C)). Here, the VF-based paradigm locations falling along each curve are shaded in their respective colours, and grid square locations are shaded in grey. Note that in (A) and (B), where larger differences between the VF-based paradigm and 8 × 8 grid were observed, GCIPL thickness varies notably within the grid square. Meanwhile, in (C), much less variation in GCIPL thickness is observed, resulting in more similar GCIPL thickness measurements between the VF-based paradigm and 8 × 8 grid. This figure was generated using Adobe Photoshop 2020 (Adobe Systems Incorporated, San Jose, CA, USA), with the GCIPL thickness map (top) generated using Matlab (Mathworks, Natick, MA, USA) and the GCIPL thickness profiles (A–C) generated using GraphPad Prism Version 7.04 (GraphPad, La Jolla, CA, USA).