Table 2 Microscopic evaluation of bijugatus extract (Mb), l-NAME and DOCA-salt on cardiac tissue.
Myocardial alterations | ||||||
|---|---|---|---|---|---|---|
Inflammatory cell infiltrate | Acute changes | Chronic changes | ||||
Haemorrhage/edema | Pyknosis/karyolsis/eosinophilic change | Hyper-trophy | Atrophy/hydropic change | Fibrosis | ||
Control | − | − | − | − | − | − |
Mb | − | − | − | − | − | − |
l-NAME | +++ (lymphocytes and macrophages) | + | + | − | + | Sub-endocardial region (× 2 foci—8.4 mm max dimension) |
l-NAME + Mb | + (lymphocytes and macrophages) | − | − | − | + | Intramural region (× 3 foci—1.8 mm) |
DOCA | − | − | − | − | − | − |
DOCA + Mb | − | − | − | − | − | Sub-endocardial region (× 1 focus—1.0 mm max dimension) |
