Table 5 Haplotype association with TMAO and TMA in the total population.

(A) Haplotype association with TMAO (n = 547, adjusted by sex + age + BMI + GFR)

1

C

G

0.4831

0.00

–

2

T

G

0.3295

0.13 (− 0.51–0.76)

0.69

3

C

A

0.1796

0.31 (− 0.46–1.08)

0.43

rare

*

*

0.0078

− 1.37 (− 4.91–2.17)

0.45

Global haplotype association p-value 0.45

(B) Haplotype association with TMA (n = 547, adjusted by sex + age + BMI + GFR)

1

C

G

0.4829

0.00

–

2

T

G

0.3297

0.02 (0–0.03)

0.039

3

C

A

0.1798

0.02 (0–0.03)

0.059

rare

*

*

0.0076

0.06 (− 0.03–0.16)

0.200

Global haplotype association p-value 0.16