Table 1 Demographics and baseline characteristics.

From: MDMA-assisted psychotherapy for treatment of anxiety and other psychological distress related to life-threatening illnesses: a randomized pilot study

 

Placebo (n = 5)

MDMA (n = 13)

Total (n = 18)

Age, mean (SD), years

53.2 (10.5)

55.5 (7.0)

54.9 (7.9)

Sex, no. (%)

Male

1 (20.0)

3 (23.1)

4 (22.2)

Female

4 (80.0)

10 (76.9)

14 (77.8)

Race, no. (%)

White/Caucasian

3 (60.0)

12 (92.3)

15 (83.3)

Black/African-American

1 (20.0)

0

1 (5.6)

White/Native American

1 (20.0)

0

1 (5.6)

 Other

0

1 (7.7)

1 (5.6)

BMI (kg/m2), mean (SD)

25.9 (3.2)

24.8 (4.0)

25.1 (3.8)

Psychiatric medical history diagnosisa, no. (%)

Anxiety

3 (60.0)

12 (92.3)

15 (83.3)

Major depression

3 (60.0)

11 (84.6)

14 (77.8)

Posttraumatic stress disorder

2 (40.0)

11 (84.6)

13 (72.2)

Insomnia

2 (40.0)

9 (69.2)

11 (61.1)

Prior ecstasy use (yes), no. (%)

3 (60.0)

7 (53.9)

10 (55.6)

 Last use, no. (%)

 2–5 years

1 (33.3)

1 (14.3)

2 (20.0)

 6–10 years

1 (33.3)

1 (14.3)

2 (20.0)

> 10 years

1 (33.3)

5 (71.4)

6 (60.0)

Pre-study psychotherapy type, no. (%)

EMDR

0

1 (7.7)

1 (5.6)

Group psychotherapy

2 (40.0)

1 (7.7)

3 (16.7)

Cognitive behavioral therapy

0

1 (7.7)

1 (5.6)

Psychodynamic

4 (80.0)

12 (92.3)

16 (88.9)

Interpersonal therapy

0

1 (7.7)

1 (5.6)

Holotropic breathwork

1 (20.0)

0

1 (5.6)

Other

3 (60.0)

6 (46.2)

9 (50.0)

None

0

0

0

Lifetime C-SSRSb, no. (%)

Positive ideation

4 (80.0)

10 (76.9)

14 (77.8)

Serious ideation

1 (20.0)

0

1 (5.6)

Positive behavior

0

3 (23.1)

3 (16.7)

STAI-Traitc, mean (SD)

57.4 (5.2)

62.5 (7.3)

61.1 (7.0)

STAI-Stated, mean (SD)

51.8 (5.3)

59.5 (11.9)

57.4 (10.9)

  1. BMI, Body Mass Index; EMDR, Eye Movement Desensitization Reprocessing; C-SSRS, Columbia Suicide Severity Rating Scale.
  2. aMedical history diagnosis: > 50% of participants indicated having these conditions.
  3. bLifetime accounts for all suicidal ideation and behavior prior to study according to participant recall and medical records. According to the C-SSRS scoring guide, scores of four or five on the suicidal ideation category are considered serious ideation and scores of one or greater are considered positive behavior or ideation.
  4. cSTAI-Trait: primary outcome measure of anxiety.
  5. dSTAI-State: secondary measure of anxiety.