Table 1 Three experimental groups of a total of eight Sprague–Dawley rats (weight range 279–336 g) divided according to the injection materials and laterality.
Group | Laterality | Materials | Conjugation | Approach | Dose (cc) | NP concentration (mg/mL), (injected volume [μL]) |
|---|---|---|---|---|---|---|
Group 1 | ||||||
Rat (n = 4) | Rt | F-MNPs (COOH terminal) | NA | Intratympanic injection | 0.05 | 1 mg/mL (700 μL) |
Lt | NO injection | |||||
Group 2 | ||||||
Rat (n = 2) | Rt | F-MNP@GM (COOH terminal) | Covalent binding (EDC/NHS) | Intratympanic injection | 0.05–0.06 | 5 mg/mL (500 μL) |
Lt | NO injection | |||||
Group 3 | ||||||
Rat (n = 2) | Rt | NO injection | NA | |||
Lt | NO injection | |||||
