Table 3 The ORs of GDM by plasma tHcy levels and HOMA-IR, age or family history of diabetes.

From: The correlation between plasma total homocysteine level and gestational diabetes mellitus in a Chinese Han population

 

Plasma tHcy levels (μmol/L)

 < 5.75

5.75–7.29

 ≥ 7.29

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

HOMA-IRa

 < 2

Ref

 

1.28 (0.83–1.99)

0.266

1.75 (1.12–2.75)

0.014

 ≥ 2

4.39 (1.92–10.04)

 < 0.001

3.68 (1.69–8.03)

0.001

5.42 (2.51–11.74)

 < 0.001

Age(years)b

 < 30

Ref

 

1.15 (0.69–1.90)

0.594

1.06 (0.62–1.81)

0.833

 ≥ 30

1.47 (0.90–2.71)

0.217

2.47 (1.34–4.54)

0.004

5.14 (2.78–9.52)

 < 0.001

Family history of T2DMc

No

Ref

 

1.10 (0.70–1.72)

0.684

1.78 (1.13–2.79)

0.013

Yes

2.32 (1.08–4.98)

0.032

6.31 (2.61–15.26)

 < 0.001

4.13 (1.78–9.56)

0.001

  1. tHcy, total homocysteine; OR, odds ratio; CI, confidence interval; HOMA‐IR, the homeostasis model assessment for insulin resistance; T2DM, type 2 diabetes mellitus.
  2. aModel adjusted for age, family history of T2DM, pre-pregnant BMI and gravidity.
  3. bModel adjusted for family history of T2DM, HOMA-IR, pre-pregnancy BMI and gravidity.
  4. cModel adjusted for age, HOMA-IR, pre-pregnancy BMI and gravidity.
  5. Statistically significant values are given in bold.
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