Table 3 The top 10 genes with significantly altered expression (FDR < 0.1) in CPM samples compared with primary CRC samples.
Rank | Gene name | Function | Fold change | FDR p value |
|---|---|---|---|---|
Reduced expression CPM samples vs. primary CRC | ||||
1 | FABP6 | Intracellular bile acid transporter | − 34.30 | 1.74 × 10–06 |
2 | DEFA6 | Cytotoxic peptide involved in host intestine defence | − 8.15 | 8.55 × 10–06 |
3 | DMBT1 | Tumour suppressor | − 6.06 | 2.43 × 10–04 |
4 | TTC38 | Protein coding gene | − 4.56 | 5.80 × 10–05 |
5 | OLFM4 | Wnt/β-catenin pathway target | − 3.77 | 1.01 × 10–04 |
6 | IGHA1 | Immune receptor | − 3.66 | 4.23 × 10–05 |
7 | CES2 | Intestinal enzyme controlling drug clearance | − 3.20 | 6.84 × 10–05 |
8 | NDUFS6 | Enzyme in electron transport chain of mitochondria | − 2.70 | 7.74 × 10–05 |
9 | P2RY11 | G-protein coupled receptor | − 2.53 | 6.37 × 10–04 |
10 | MUC2 | Encodes a mucinous intestinal coating | − 2.34 | 7.22 × 10–04 |
Increased expression CPM samples vs. primary CRC | ||||
1 | CD53 | Tetraspanin | 7.29 | 5.87 × 10–05 |
2 | CYR61 | Extracellular signalling protein | 4.24 | 3.12 × 10–04 |
3 | CXCL12 | G-protein coupled receptor | 3.64 | 9.25 × 10–04 |
4 | NR2F1 | Nuclear hormone receptor and transcriptional regulator | 3.53 | 7.09 × 10–04 |
5 | CTGF | Connective tissue growth factor | 3.49 | 1.55 × 10–04 |
6 | CSTB | Cystatin | 3.41 | 6.13 × 10–04 |
7 | TSC22D3 | Anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper | 3.36 | 3.94 × 10–04 |
8 | DCN | Tumour suppressor gene | 3.30 | 6.19 × 10–05 |
9 | PTEN | Tumour suppressor gene | 3.25 | 9.28 × 10–04 |
10 | NF-κBIA | Inhibits the NF-κB transcription factor | 3.24 | 1.06 × 10–04 |
