Figure 3 | Scientific Reports

Figure 3

From: Glucocorticoid-dependent transcription in skin requires epidermal expression of the glucocorticoid receptor and is modulated by the mineralocorticoid receptor

Figure 3

Heatmap and gene ontology clustering of Differentially Expressed Genes (DEGs) in CO and MREKO skin. (a) Heatmap of Differentially Expressed Genes (DEGs) in CO and MREKO skin, per genotype and treatment. Note that samples first cluster by treatment and then by genotype. The heat map was generated using the 'pheatmap' package (v 1.0.12) in the R statistical language (v 3.4; https://CRAN.R-project.org/package=pheatmap). (b) Log2 fold-change Dex/V vs Log10 adj-pvalue Dex/V. (c) Gene ontology (GO) clustering of DEGs that overlapped in CO and MREKO skin (top); or were uniquely identified in MREKO (bottom). The GO process, total count and percentage of genes, and p value, are indicated.

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