Figure 4
From: Recurring urothelial carcinomas show genomic rearrangements incompatible with a direct relationship
Recurring metachronous tumors show aberrations incompatible with direct relationship. (a) A typical example is shown for case P12 in which one distinct AI on chromosome 2p and three on chromosome 9 makes tumor P12_S1 incompatible with being the origin of tumor P12_S2. This incompatibility is reciprocal as the allelic losses on chromosomes 6q and 8p in tumor P12_S2 cannot be regained in tumors P12_S1. (b) Tumors P7_S1 shows an LOH in distal 4q (haplotypes A, A,) tumor P7_S2 show a gain of the region (haplotypes A, A, A, B) and tumor P7_S3 has a gain of the same region with the haplotypes A, A, B, B. This makes the first tumor P7_S1 incompatible with the two following tumors. Tumors P7_S1 and P7_S2 shared a loss on arm 7q making them incompatible with P7_S3. Tumors P7_S3, and P7_S2 shows an allelic imbalance in distal 6p as well as in proximal 6q, making it incompatible with tumor P7_S1, and tumor P7_S3 shows an allelic imbalance of distal 6q making it incompatible with tumors P7_S1 and P7_S2. Figure was created in R v3.6 (https://www.r-project.org/) using TAPS v2 package (https://patchwork.r-forge.r-project.org/).
